Midfielder Simon Davies is likely to return to the Fulham side after suspension.
Striker Diomansy Kamara could find himself named as a substitute.
Jari Litmanen has returned to full training with Fulham following a recent heart scare but will not be involved on Saturday.
Litmanen, 37, returned to Finland earlier this week after suffering heart palpitations.
Fulham are without midfielder Leon Andreasen who is suspended after being sent off in last weekend's 1-0 defeat to West Ham but Hameur Bouazza returns from a shoulder injury.
Manchester United (from):
Van der Sar, Brown, Vidic, Ferdinand, Evra, Ronaldo, Carrick, Fletcher, Hargreaves,
Nani, Rooney, Tevez, Scholes, O'Shea, Saha, Kuszczak, Anderson, Park, Simpson, Eagles.
Ryan Giggs is doubtful for Manchester United's Barclays Premier League match at
Fulham on Saturday because of a calf strain.
The former Wales midfielder looks likely to sit out the game with a Champions League
date to follow on Tuesday against Lyon.
Nemanja Vidic and Patrice Evra have recovered from a calf strain and a stomach virus
respectively but Gary Neville and Mikel Silvestre remain sidelined as United aim
to close a three-gap on leaders Arsenal.