Manchester United defender Rio Ferdinand could face Roma in the Champions League on Wednesday at Old Trafford despite suffering a foot injury in the draw at Middlesbrough.

Manager Sir Alex Ferguson is still to announce his decision  over Ferdinand's fitness.

Should the England star fail to make it then either Gary Neville or Mikael Silvestre are poised to return to the team for this quarter-final second leg match.

Ferguson said: "I am hoping Rio will play. His scan was clear, that was the important thing.

"Therefore we are hoping we can get him fit to face Roma.

"We will report tomorrow at 11am, so he will have to do something at that time."

Paul Scholes is set to make his 100th Champions League appearance while Nani could return to the squad after a thigh problem.

United are looking look to build on their 2-0 advantage from the first leg but Nemanja Vidic (knee), Darren Fletcher (knee) and Louis Saha (hamstring) remain sidelined through injury.

Roma head to Manchester on the back of a 3-2 victory over Genoa at the weekend and buoyed by the return of Simone Perrotta following his suspension.

They are not, though, able to call on captain and favourite son Francesco Totti due to an injury that also kept him out of the first leg.

Alberto Aquilani is not match fit and is unlikely to figure, meaning David Pizarro could win a recall for the Italians.